INTELLECTUAL PROPERTY |
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BioActives proprietary ingredients are developed within a patent strategy that enhances the probability of final issuance. To date the Company has been issued all patents it has filed and has every expectation that the patents pending will result in issued patents as well.
PATENTS
A method for concentrating trans-lutein esters from marigold oleoresin, which includes blending the oleoresin with a solvent and a co-solvent of lower alkanols and recovering a precipitate enriched with trans-lutein esters at a temperature of above 22.degree. C. The recovery of the trans-lutein esters is greater using the alkanol blend than when using only a lower alkanol in the said blend. The process is most useful using a lower-grade, commercially available oleoresin, thereby helping small producers, who do not have access to higher-grade oleoresin made through backward integration to marigold cultivation and harvest.
The present invention is based on the unexpected discovery that CoQ-10 can be made commercially in a highly bioavailable form suitable for topical, sublingual formulations, or for oral ingestion. complex. Complexation in general with .gamma.- or .alpha.-cyclodextrin improved the cellular uptake of CoQ-10 as compared to water dispersible liposomal or micellar forms of CoQ-10. Thus, the present invention includes a highly bioavailable CoQ-10/cyclodextrin complex for use in the nutritional supplement, oral care, and pharmaceutical industry.
A practical and effective process for isolating and purifying mixed carotenoids containing higher concentrations of specific compounds, such as all-trans lutein, without the use of harmful organic solvents, is disclosed. The process employs hydrolysis of carotenoid esters in a mixture of isopropanol, water, and alkali to separate the carotenoids from other impurities. The carotenoids are purified further using aqueous precipitation, followed by centrifugation and drying under vacuum. The product is a fine crystalline powder with very low residual solvents (hexane 0.22 ppm; isopropanol 0.53 ppm) suitable for human consumption, either in nutritional supplements or as a food additive.
The company conducted the research, wrote and filed the patent for its client Protective Factors. PATENTS PENDING
 Water-dispersible policosanol cyclodextrin complex and method of its production
Oral-care formulations comprising highly-bioavailable Coenzyme Q10 cyclodextrin complex
LICENSING IN
North American marketing rights for Phthalides from Celery Seeds
LICENSING OUT
Highly bioavailable ingredient for oral-care formulations
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